Allosteric inhibition of antiapoptotic MCL-1
نویسندگان
چکیده
منابع مشابه
Ubiquitin-independent degradation of antiapoptotic MCL-1.
Antiapoptotic myeloid cell leukemia 1 (MCL-1) is an essential modulator of survival during the development and maintenance of a variety of cell lineages. Its turnover, believed to be mediated by the ubiquitin-proteasome system, facilitates apoptosis induction in response to cellular stress. To investigate the contribution of ubiquitinylation in regulating murine MCL-1 turnover, we generated an ...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2016
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.3223